口腔所進食的食物，途經各器官後便會來到小腸，絕大部份的營養最終將透過空腸(Jejunum)進入血液循環系統裡頭，再分配予各身體細胞；627Please respect copyright.ＰＥＮＡＮＡ8AzQQ0rimo
我們的空腸內壁擁有著絨毛狀的結構(villi)，將大大增加遇上及吸取營養的效率，以達其消化及吸收營養的重任。627Please respect copyright.ＰＥＮＡＮＡPQZc4mUadR
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627Please respect copyright.ＰＥＮＡＮＡQxtb1fv4Qf
627Please respect copyright.ＰＥＮＡＮＡT3frIbHqG9
（圖2）食得是褔，著得是祿。627Please respect copyright.ＰＥＮＡＮＡAxC8tTNtLM
患有短腸症候群(Short Bowel Syndrome，每年約每一百萬個小童便有三名患者)或其他腸道疾病問題的兒童，因著空腸長度有機會出現過短的狀況，很多時候下並沒能夠吸取足夠營養支撐正常成長。627Please respect copyright.ＰＥＮＡＮＡl2KlJglm7B
627Please respect copyright.ＰＥＮＡＮＡojpcSjyO3x
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嚴重的情況，便需要進行器官移植。627Please respect copyright.ＰＥＮＡＮＡJUC5g0cqg8
627Please respect copyright.ＰＥＮＡＮＡi2k6XWGv3x
只不過，適用的器官並不是話來就來，而且亦有不少個案出現器官排斥問題，引發一連串的併發症。627Please respect copyright.ＰＥＮＡＮＡh89zJa0S8Y
627Please respect copyright.ＰＥＮＡＮＡQsvd745Rzn
（圖3）為了紓困現狀，有科學家在近日發表文章（Ref1)，嘗試提出方法解決現時所面對的困局–627Please respect copyright.ＰＥＮＡＮＡj2cVHjLY7L
627Please respect copyright.ＰＥＮＡＮＡ2LiDegDBtA
抽取患者的腸道細胞，以體外的方式在實驗室進行培植，製造出新一條的空腸。627Please respect copyright.ＰＥＮＡＮＡlNfNtrEOxg
而因著器官是由患者本身的細胞而來，出現排斥的機會亦順然大幅度能夠減低下來。627Please respect copyright.ＰＥＮＡＮＡf9CZMShP5f
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627Please respect copyright.ＰＥＮＡＮＡIY0a6emH7Q
這次研究中，他們找來了28名歲數從3個月大至15歲的小童，從某部份的病人體內拿取2mm左右的腸道樣本，在實驗室內培植兩個月左右的時間，得出俱備空腸功能的類器官627Please respect copyright.ＰＥＮＡＮＡuDwoSBq3jw
(Organoid);627Please respect copyright.ＰＥＮＡＮＡUbDUH6qQ4l
627Please respect copyright.ＰＥＮＡＮＡx4PYtCjoP2
類器官可看成為半完成物，有著器官的關鍵功能，但外貌及個別特徵始終與完整器官差天共地。627Please respect copyright.ＰＥＮＡＮＡBOfRxXJ2d6
627Please respect copyright.ＰＥＮＡＮＡ2RdZxgUdmr
同時間，他們亦拿取病人腸道一小節，把所有的細胞清除得一乾二淨，用作為日後移植用的基座(Scaffold)。627Please respect copyright.ＰＥＮＡＮＡdrM9084pvK
之所以要沿用病人的腸道作為基座，原因是病人腸道本質上有著引導類器官繼續發展成型的能力，而這種本質現今科技上還沒能完完全全利用其他物料成功複製出來。627Please respect copyright.ＰＥＮＡＮＡnAILkQKwkW
627Please respect copyright.ＰＥＮＡＮＡWbXckP1H9P
他們把類器官培植在基座上一段時間後，再嘗試移植到老鼠身體上，箇中亦證實得到類器官在老鼠體內擁有發展成為腸道的能力。627Please respect copyright.ＰＥＮＡＮＡjHDtPhP6s0
627Please respect copyright.ＰＥＮＡＮＡaRDO79BkYj
將類器官移植回到病人體內這一步，無疑還有一段距離才能實行。627Please respect copyright.ＰＥＮＡＮＡkk3czTHf9F
但這研究在老鼠身上所得出的成果，至少證實得到這個大方向是有著實際應用上的可行性，並非紙上談兵風花雪月，而是為日後實際套用在病人方面上奠下了一重要的理論基礎。627Please respect copyright.ＰＥＮＡＮＡBhna3rdejr
627Please respect copyright.ＰＥＮＡＮＡQCfgBbdSR9
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。627Please respect copyright.ＰＥＮＡＮＡ4fRUYrgqhw
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc627Please respect copyright.ＰＥＮＡＮＡsTGEXRidQF
627Please respect copyright.ＰＥＮＡＮＡciE4qFkwJg
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。627Please respect copyright.ＰＥＮＡＮＡm901PJMft7
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Link:627Please respect copyright.ＰＥＮＡＮＡBTn6tKL3RQ
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio627Please respect copyright.ＰＥＮＡＮＡ5vrj4b72d0
627Please respect copyright.ＰＥＮＡＮＡVxm6FhHoHb
627Please respect copyright.ＰＥＮＡＮＡYCFPAqQ6Ns
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。627Please respect copyright.ＰＥＮＡＮＡy7jk3sq11q
627Please respect copyright.ＰＥＮＡＮＡEA2y8mi0rO
627Please respect copyright.ＰＥＮＡＮＡ8DYW6QQzXx
Ref1:https://www.nature.com/articles/s41591-020-1024-z627Please respect copyright.ＰＥＮＡＮＡdAOX0hnYBX
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