癌細胞的新陳代謝與普通細胞有著顯著的分別,原因是癌細胞需要截然不同的新陳代謝來滿足生長的需要。820Please respect copyright.PENANAYWHMHMDpnl820Please respect copyright.PENANAI82YWhxYZq
但是,當癌細胞從原有位置轉移到另一位置後,其新陳代謝有會否有所轉變呢?820Please respect copyright.PENANAqKfVqa7yqs
820Please respect copyright.PENANAfuvdqfYhaz
820Please respect copyright.PENANA3o70ZzBI2y
(圖2)mTORC1是其中一隻掌管細胞生長的蛋白質,而有研究(Ref1)指出,從乳癌轉移到肺部的癌細胞,其mTORC1所帶來的效果更為強大,能令癌細胞生長得更快。820Please respect copyright.PENANA98q6qnZWlv820Please respect copyright.PENANA85lmJcLk0Y
820Please respect copyright.PENANAOnnNaZRnbK
(圖3)科學家發現,肺部含有充足的Pyruvate代謝物,而利用藥物阻擋「乳癌轉移過來的肺癌」吸收Pyruvate的話,便能減低mTORC1的功效。820Please respect copyright.PENANAMCoKsmBNT8820Please respect copyright.PENANAEsho0Ja64w
820Please respect copyright.PENANA0b6e8shrvF
但奇怪的是,用藥物阻擋原發腫瘤乳癌吸收Pyruvate的話,mTORC1的功效並不會有所減低,腫瘤生長的速度並無任何特別變化。820Please respect copyright.PENANA1ltdVnxuK0
820Please respect copyright.PENANAOBPZpOZzMY
這顯示出,癌細胞從原有地方轉移到另一位置後,其新陳代謝亦有著顯著的變化。820Please respect copyright.PENANAnckBrCvQ56
這有可能是因為第二處位置的生長環境有所不同,故此癌細胞需要調節其新陳代謝來適應新環境。820Please respect copyright.PENANAvObvbwC1VM
820Please respect copyright.PENANAKxaCESiF2t
在乳癌轉移到肺部的癌細胞,我們可透過針對Pyruvate的吸收來減慢他們的生長,但這是否只適用於從其他位置轉移到肺部的癌細胞,以及乳癌轉移到其他位置的癌細胞,那還需要進一步的研究確實。820Please respect copyright.PENANAhLPPQwCgXp
820Please respect copyright.PENANA4FVzbAkDfN
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。820Please respect copyright.PENANAsBiDjUGqVP
820Please respect copyright.PENANAGuaxMJ1ftH
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc820Please respect copyright.PENANAzySg7CMyG1
820Please respect copyright.PENANATGt9foUdis
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。820Please respect copyright.PENANAiUDiP28TOS
820Please respect copyright.PENANACEOewZT2u4
Link:820Please respect copyright.PENANA1PGGSWQOkU
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio820Please respect copyright.PENANAb1Y5a9oqK7
820Please respect copyright.PENANAZgkUUFllxF
820Please respect copyright.PENANApK0SjndPnW
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。820Please respect copyright.PENANAF07DVnAmNu
820Please respect copyright.PENANAFRZigayfkf
Ref1:https://www.sciencedirect.com/science/article/pii/S1097276520308273820Please respect copyright.PENANAmep6L1optS