癌細胞的新陳代謝與普通細胞有著顯著的分別,原因是癌細胞需要截然不同的新陳代謝來滿足生長的需要。810Please respect copyright.PENANA3rtFwtLriC810Please respect copyright.PENANAYFypuEVAX5
但是,當癌細胞從原有位置轉移到另一位置後,其新陳代謝有會否有所轉變呢?810Please respect copyright.PENANApksqRXrwQo
810Please respect copyright.PENANAuz91uf7JVf
810Please respect copyright.PENANAOzXbZuN4XR
(圖2)mTORC1是其中一隻掌管細胞生長的蛋白質,而有研究(Ref1)指出,從乳癌轉移到肺部的癌細胞,其mTORC1所帶來的效果更為強大,能令癌細胞生長得更快。810Please respect copyright.PENANAC2Fj7zfiS9810Please respect copyright.PENANAJGpVjvL7qK
810Please respect copyright.PENANAF1NuwSmaYa
(圖3)科學家發現,肺部含有充足的Pyruvate代謝物,而利用藥物阻擋「乳癌轉移過來的肺癌」吸收Pyruvate的話,便能減低mTORC1的功效。810Please respect copyright.PENANAfiCpbZ71e4810Please respect copyright.PENANAx30ydJFBmG
810Please respect copyright.PENANAEdi7csSPeU
但奇怪的是,用藥物阻擋原發腫瘤乳癌吸收Pyruvate的話,mTORC1的功效並不會有所減低,腫瘤生長的速度並無任何特別變化。810Please respect copyright.PENANArHzt76FmYh
810Please respect copyright.PENANASVhN0oB2cs
這顯示出,癌細胞從原有地方轉移到另一位置後,其新陳代謝亦有著顯著的變化。810Please respect copyright.PENANA3bvYvIm6ra
這有可能是因為第二處位置的生長環境有所不同,故此癌細胞需要調節其新陳代謝來適應新環境。810Please respect copyright.PENANAIHv2hWxj7L
810Please respect copyright.PENANAPSf5zl6ksj
在乳癌轉移到肺部的癌細胞,我們可透過針對Pyruvate的吸收來減慢他們的生長,但這是否只適用於從其他位置轉移到肺部的癌細胞,以及乳癌轉移到其他位置的癌細胞,那還需要進一步的研究確實。810Please respect copyright.PENANATiFU2xRGff
810Please respect copyright.PENANA9vp8tgPJst
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。810Please respect copyright.PENANArb9qf4Oh0Y
810Please respect copyright.PENANAKrC7sKpEg0
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc810Please respect copyright.PENANAz3nR7sEvva
810Please respect copyright.PENANAqOxQRgOhqv
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。810Please respect copyright.PENANA9qSHusbR11
810Please respect copyright.PENANAycFF4HoIkq
Link:810Please respect copyright.PENANAFxO71vnRes
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio810Please respect copyright.PENANAN3t9tOr33u
810Please respect copyright.PENANAjfZ0tRREXT
810Please respect copyright.PENANAGjfP5iL7lk
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。810Please respect copyright.PENANAFjKn18TJtK
810Please respect copyright.PENANAlPhgAxbDST
Ref1:https://www.sciencedirect.com/science/article/pii/S1097276520308273810Please respect copyright.PENANAWyOz9wFnLw