化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?559Please respect copyright.PENANAibrgigDfow559Please respect copyright.PENANAMW53aQ4Anj
559Please respect copyright.PENANARWw8qtOT6U
(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。559Please respect copyright.PENANAdfdc0bz6YJ
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。559Please respect copyright.PENANAr8a2ZI6Wqk559Please respect copyright.PENANA82oCOlmiCK
559Please respect copyright.PENANAdCSCkKq1DN
如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。559Please respect copyright.PENANASCnxAp98jT
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。559Please respect copyright.PENANAthj3Srp4yG
559Please respect copyright.PENANAEeVnu2ZctX
(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。559Please respect copyright.PENANAbGvWAvEk1y559Please respect copyright.PENANAfqzm7t0Oiu
559Please respect copyright.PENANAeFVYIaT6yr
559Please respect copyright.PENANAb9Tehkdrtv
(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。559Please respect copyright.PENANAdRPdMFMrl7559Please respect copyright.PENANAu3yB9Qb1gm
559Please respect copyright.PENANAHUTbBZssCJ
但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。559Please respect copyright.PENANAxWMufgzpJS
559Please respect copyright.PENANAvSUsiXebe4
並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。559Please respect copyright.PENANA9skJpYuB9k
559Please respect copyright.PENANAwo1SwZY2Du
若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。559Please respect copyright.PENANAwybwPbOi64
559Please respect copyright.PENANAcCIfASVWE2
559Please respect copyright.PENANAnn3khUwA3l
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。559Please respect copyright.PENANAJDJ9RetF6q
559Please respect copyright.PENANAEvOwCRIseS
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc559Please respect copyright.PENANAIAZJKRMTjn
559Please respect copyright.PENANAvQe0C9IegG
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。559Please respect copyright.PENANAVjncjVuq1e
559Please respect copyright.PENANA7S3Rb2EmsW
Link:559Please respect copyright.PENANAXCiGhz6Qxz
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio559Please respect copyright.PENANAZm0bi1uyig
559Please respect copyright.PENANAD69jQpQgfR
559Please respect copyright.PENANAtMUyErCPwY
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。559Please respect copyright.PENANAgp0o04URkZ
559Please respect copyright.PENANADxmGCT5tp2
Ref1:https://www.nature.com/articles/s41467-020-14928-3559Please respect copyright.PENANAaiULO8zbbR