現今至少有兩間公司的人造抗體(LY/REGN)被緊急認可為武肺的治療方法。551Please respect copyright.PENANAnvF29PzYUG551Please respect copyright.PENANAZ4vfftWBaV
551Please respect copyright.PENANAb6cqm0KYv1
但基於這兩種人造抗體需經由血管注射,其間病人需卧床約一小時間,且需求人手密切監察整個過程,實際運行的成本非常高昂,因此未能普及。551Please respect copyright.PENANAx7Z9dxSsHk
551Please respect copyright.PENANAlTyiJmoLSS
更甚的是,有數據顯示當人造抗體經血管注射後,能抵達肺部裡頭的數量少至有少(血液抗體含量比肺部抗體含量高出200-500倍有多),且已知當今的武肺病毒變種能有效躲避兩間公司的人造抗體追捕,使至人造抗體的地位日漸式微。551Please respect copyright.PENANA8ndHgx6q3T
551Please respect copyright.PENANA0DM8z2SbMl
551Please respect copyright.PENANAvxlBEam2gD
(圖2)武肺病毒最主要的作惡地方是肺部,要解決肺部抗體含量過少的問題,其中一道手段就是從鼻腔注射人造抗體,使其能較易直達肺部。551Please respect copyright.PENANAuTAvkwPLnr551Please respect copyright.PENANAOWVYGn9A4K
551Please respect copyright.PENANAmX15Sj0IPP
從老鼠模型實驗中,可以見到往鼻腔注射人造抗體後,抗體(紅黃色區域)會聚集在鼻腔(N)及肺部(Lu)裡頭。551Please respect copyright.PENANA8riKCpS9Bk
551Please respect copyright.PENANA1iqiZMJUwo
551Please respect copyright.PENANAozjX9CeUNE
(圖3)至於解決武肺變種的問題,其中一手段就是將五個單一抗體連結成一個個體(五合一),利用「龐大」的身驅阻礙病毒進入細胞。551Please respect copyright.PENANAfbBtvpZKbi551Please respect copyright.PENANA9q51v56nnb
551Please respect copyright.PENANAnI1J3zfWY5
在老鼠實驗中,鼻噴式的五合一抗體能有效阻隔英國及巴西變種等病毒,且有著預防及治療武肺的功效,同時亦沒有對老鼠的體重和明顯特徵做成任何影響。551Please respect copyright.PENANAaaeEBPBrai
551Please respect copyright.PENANAF2ItAueHVe
若能順利通過人體臨床實驗,定必為世界的安定起來重要的作用。551Please respect copyright.PENANAZcsFeXyAdE
551Please respect copyright.PENANAGr9mxWJjmx
551Please respect copyright.PENANAyXcvito9zF
551Please respect copyright.PENANAV6BSk2U607
551Please respect copyright.PENANAZWw4Qeohwk
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。551Please respect copyright.PENANACHgAfpcLxx
551Please respect copyright.PENANANyjVdXb879
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc551Please respect copyright.PENANAfgHBN8uUiQ
551Please respect copyright.PENANAQyUDOFi7HP
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。551Please respect copyright.PENANAG0lE6xxr3j
551Please respect copyright.PENANATc7PbxWdcD
Link:551Please respect copyright.PENANAfjPj7sg4E4
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio551Please respect copyright.PENANAVzNdnc5sri
551Please respect copyright.PENANAeyuU0oHr76
551Please respect copyright.PENANA5DoMo3pPDM
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。551Please respect copyright.PENANAxk1aXdK7Fm
551Please respect copyright.PENANAFUrBegAoEm
Ref1:https://www.nature.com/articles/s41586-021-03673-2_reference.pdf551Please respect copyright.PENANANdNKDb7nJM