皮膚受傷的時候，大多數的情況下都會出現結焦情況，過一段時間後傷口便會縫合。989Please respect copyright.ＰＥＮＡＮＡVmhNEA5lyI
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有時候，皮膚會留有疤痕，但又有一些情況下會不留痕跡般似的進行修復，就像沒有事發生過一樣。989Please respect copyright.ＰＥＮＡＮＡNbyPU4rWea
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究竟最終會否留有疤痕，是看幸運還是甚麼呢？989Please respect copyright.ＰＥＮＡＮＡhavFQwxPFy
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（圖2）近日，有科學家發表文章(Ref1)，對此作出了一個頗為完滿的解答。989Please respect copyright.ＰＥＮＡＮＡpdfBMSrqAG
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他們在老鼠耳仔上開一個細洞，然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後，傷口會完美修復不留疤。989Please respect copyright.ＰＥＮＡＮＡRZBFeO2tcU
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而在缺乏TRPA1神經細胞的老鼠，就算塗上(IMQ)，傷口始終會留有疤痕，表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。989Please respect copyright.ＰＥＮＡＮＡdlQcEjEyT8
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（圖3）他們進行了一系列的實驗，最終找出了箇中機制，以下為最簡化版本。989Please respect copyright.ＰＥＮＡＮＡLq0bo3fsLU
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1.傷口塗上IMQ後，將會引起發炎作用。989Please respect copyright.ＰＥＮＡＮＡMd7qmyPFXf
2.發炎作用刺激TRPA1神經細胞。989Please respect copyright.ＰＥＮＡＮＡ1cKPZTP2Ym
3.免疫系統細胞（dermal dendritic cells、γδ T cells）被傳召前來。989Please respect copyright.ＰＥＮＡＮＡMtNqMsP69U
4.免疫系統細胞釋出相關物質（Interlunkin17、22、23）。989Please respect copyright.ＰＥＮＡＮＡMKLN7yAAOs
5.一系列的過程發生過後，肌膚完美修復。989Please respect copyright.ＰＥＮＡＮＡ7pnAtbuJON
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此研究的結果針對於老鼠的皮膚癒合情況，未必能套用在人類身上，需要作出人體試驗才能廣泛證實此結果。989Please respect copyright.ＰＥＮＡＮＡfM1cBZJLCM
另外，IMQ的塗用時機還需要進一步確認，何時觸發發炎作用才是適當的時機還需要一系列的測試。989Please respect copyright.ＰＥＮＡＮＡlHcngyns4A
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不過有一點非常重要的是，當人類皮膚受傷的時候，自身是不會主動觸動TRPA1神經細胞。989Please respect copyright.ＰＥＮＡＮＡe5IYkyui6j
若然整個結果能套用在人類身上的話，那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞，觸發一系列的過程使傷口以不留疤痕的方式完美癒合！989Please respect copyright.ＰＥＮＡＮＡQNJdM1iDqh
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。989Please respect copyright.ＰＥＮＡＮＡMz8iTwPy8E
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc989Please respect copyright.ＰＥＮＡＮＡNT1m6KVU1w
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。989Please respect copyright.ＰＥＮＡＮＡGmrGxrcUnk
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Link:989Please respect copyright.ＰＥＮＡＮＡs35FsjxbdW
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio989Please respect copyright.ＰＥＮＡＮＡarWOHruQAn
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最後亦請幫一幫忙簽署袁爸的白宮呈請，幫忙為香港出一份力。989Please respect copyright.ＰＥＮＡＮＡzZ1XV2xB68
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now989Please respect copyright.ＰＥＮＡＮＡ99k4bDDenV
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。989Please respect copyright.ＰＥＮＡＮＡrajzkznr56
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Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683
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