上兩集簡述了癌細胞缺氧的成因，以及缺氧導致癌細胞相對上更為依賴葡萄糖作新陳代謝用途。660Please respect copyright.ＰＥＮＡＮＡaLxpbmLfJ5
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三十秒科學–腫瘤的周遭環境660Please respect copyright.ＰＥＮＡＮＡGySnWlgml8
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三十秒科學–癌細胞嗜糖的原因660Please respect copyright.ＰＥＮＡＮＡSj4ToaGNPM
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今集我們會講述缺氧對癌細胞自身發展的其中一道好處。660Please respect copyright.ＰＥＮＡＮＡz4vVrLWMXt
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（圖2）當DNA出現異變的時候，細胞裡名為p53的蛋白質便會出手幫忙，號令細胞停止生長(Cell cycle arrest)，給予時間讓其他蛋白質幫忙協助修復DNA。660Please respect copyright.ＰＥＮＡＮＡxDhKD7Vzph
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若果細胞最後還是無法處理修復DNA的工作，p53便會指示細胞趨向死亡程序(Apoptosis)。660Please respect copyright.ＰＥＮＡＮＡAq2wb4Qchc
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腫瘤的出現，是無數DNA變異得出來的成果。因此在這方面來看，p53是防止癌細胞出現的好幫手，因為p53會確保細胞的DNA不會出現變異，或指令出現DNA變異的細胞消失。660Please respect copyright.ＰＥＮＡＮＡXYokif6eit
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但是，有一點非常矛盾的是，大部份普通細胞的p53蛋白質表達率非常低，它能否防止癌細胞出現這一點使人存疑。660Please respect copyright.ＰＥＮＡＮＡy7sfiwWiWl
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（圖3）事實上，非常諷刺的是，氧氣含量越低的話，P53蛋白質的表達率便會越高。660Please respect copyright.ＰＥＮＡＮＡgkEXw8J5cd
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而在缺氧的環境下，擁有p53的蛋白質的細胞便會自動進行死亡。660Please respect copyright.ＰＥＮＡＮＡjk7g7YwNHL
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（圖4）重大的問題是，有部份缺氧的癌細胞會發展出變異版本的p53，失去原有的功能。660Please respect copyright.ＰＥＮＡＮＡXF5bQUFmYZ
在缺氧施加的壓力下，擁有正常p53版本的細胞會一一死去，變相幫忙篩選出擁有變異版本p53的細胞，使它們逐漸成為大多數。660Please respect copyright.ＰＥＮＡＮＡxfrtGhVfb4
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而這些擁有變異版本p53的細胞，修復DNA的能力會大幅度被削弱，因而加劇了DNA變異速度，促成腫瘤繼續長大。660Please respect copyright.ＰＥＮＡＮＡPLClnhRCFf
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（圖5）圖中為腫瘤形成的其中一道概論，癌細胞自製的缺氧環境，變相提供了一道挑選擁有更強DNA變異能力細胞的環境。660Please respect copyright.ＰＥＮＡＮＡPo3VaKFPmU
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現實中大部分的的癌細胞均擁有p53變異，而擁有p53變異的細胞更具抵抗化療藥物cis-platin的能力。660Please respect copyright.ＰＥＮＡＮＡTpUuxvBjYS
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除缺氧外，大陽的紫外光亦是促使p53變異的好幫手，不少皮膚癌細胞均出現至少一處的p53變異。660Please respect copyright.ＰＥＮＡＮＡfUpJAWx46s
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那些不塗防曬便與陽光玩遊戲的人，一直是在玩命。660Please respect copyright.ＰＥＮＡＮＡAjaZy8ZaOE
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。660Please respect copyright.ＰＥＮＡＮＡdnDaU4Lstw
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Ref1:https://pubmed.ncbi.nlm.nih.gov/8538748/660Please respect copyright.ＰＥＮＡＮＡrkwWN1bDRR
