減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1065Please respect copyright.ＰＥＮＡＮＡQu57jh6D9j
1065Please respect copyright.ＰＥＮＡＮＡfVKbYGzzoy
1065Please respect copyright.ＰＥＮＡＮＡztRO5WUkbI
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1065Please respect copyright.ＰＥＮＡＮＡS3yBxFK0y9
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1065Please respect copyright.ＰＥＮＡＮＡTsAmGg5N6E
1065Please respect copyright.ＰＥＮＡＮＡGRgIicCb0N
1065Please respect copyright.ＰＥＮＡＮＡAuauGDVbKW
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1065Please respect copyright.ＰＥＮＡＮＡM42r1IyRHE
1065Please respect copyright.ＰＥＮＡＮＡwpyct8PmsA
1065Please respect copyright.ＰＥＮＡＮＡOjfbwOqfBj
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1065Please respect copyright.ＰＥＮＡＮＡcJP95veQge
1065Please respect copyright.ＰＥＮＡＮＡdNrC3EVmPJ
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1065Please respect copyright.ＰＥＮＡＮＡO3kkL96KkY
1065Please respect copyright.ＰＥＮＡＮＡ3Ar366YzM6
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1065Please respect copyright.ＰＥＮＡＮＡQitnmDMTz8
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1065Please respect copyright.ＰＥＮＡＮＡuA2FHqVYci
1065Please respect copyright.ＰＥＮＡＮＡqiqjN4EjKk
1065Please respect copyright.ＰＥＮＡＮＡLg3YmlIybF
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1065Please respect copyright.ＰＥＮＡＮＡIL0OcENDVz
1065Please respect copyright.ＰＥＮＡＮＡvsPjkFDrTO
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第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1065Please respect copyright.ＰＥＮＡＮＡMhFe3vlEgK
1065Please respect copyright.ＰＥＮＡＮＡx4OrNhHots
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1065Please respect copyright.ＰＥＮＡＮＡIGTa8hfUcS
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1065Please respect copyright.ＰＥＮＡＮＡxS92JgSPp1
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1065Please respect copyright.ＰＥＮＡＮＡIC4oCABAen
1065Please respect copyright.ＰＥＮＡＮＡEmNQEdneol
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1065Please respect copyright.ＰＥＮＡＮＡbqkn5BMzSw
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Link:1065Please respect copyright.ＰＥＮＡＮＡOw4PSHSH19
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1065Please respect copyright.ＰＥＮＡＮＡg5j3WVUCve
1065Please respect copyright.ＰＥＮＡＮＡLVPjTT5CFp
1065Please respect copyright.ＰＥＮＡＮＡGBtLkyiyiD
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1065Please respect copyright.ＰＥＮＡＮＡcrvdRJMn1D
1065Please respect copyright.ＰＥＮＡＮＡgjc2zsQ8as
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1065Please respect copyright.ＰＥＮＡＮＡrZf81zKOCP
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661065Please respect copyright.ＰＥＮＡＮＡ0odjBA9U0t
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1065Please respect copyright.ＰＥＮＡＮＡgvAVcsbIJx
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1065Please respect copyright.ＰＥＮＡＮＡH17rDFT00G
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1065Please respect copyright.ＰＥＮＡＮＡSF6zLYfHmX
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