減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1067Please respect copyright.ＰＥＮＡＮＡW7uaakJq6Z
1067Please respect copyright.ＰＥＮＡＮＡUvP1xRrYj2
1067Please respect copyright.ＰＥＮＡＮＡQwkIuQAa9B
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1067Please respect copyright.ＰＥＮＡＮＡOe4jOAXN2J
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1067Please respect copyright.ＰＥＮＡＮＡkRUwHeYzj3
1067Please respect copyright.ＰＥＮＡＮＡk2NjwzVi2c
1067Please respect copyright.ＰＥＮＡＮＡuo6L46aMDs
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1067Please respect copyright.ＰＥＮＡＮＡqEO1wzMj8L
1067Please respect copyright.ＰＥＮＡＮＡN5CxiygPtE
1067Please respect copyright.ＰＥＮＡＮＡOymZfJr48n
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1067Please respect copyright.ＰＥＮＡＮＡCSD0ouqt0n
1067Please respect copyright.ＰＥＮＡＮＡfSvq6euGtB
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1067Please respect copyright.ＰＥＮＡＮＡ2NLdjhExnt
1067Please respect copyright.ＰＥＮＡＮＡnbXzchrIbr
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1067Please respect copyright.ＰＥＮＡＮＡUaeNGCmeSR
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1067Please respect copyright.ＰＥＮＡＮＡXCgdjxyN0i
1067Please respect copyright.ＰＥＮＡＮＡV2tekq0VH8
1067Please respect copyright.ＰＥＮＡＮＡoltHpW9awN
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1067Please respect copyright.ＰＥＮＡＮＡXpsNqGwXdl
1067Please respect copyright.ＰＥＮＡＮＡmsiN0TttuM
1067Please respect copyright.ＰＥＮＡＮＡe3tqOFWS0X
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1067Please respect copyright.ＰＥＮＡＮＡMvMp13ryIk
1067Please respect copyright.ＰＥＮＡＮＡP1yMHsK5BY
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1067Please respect copyright.ＰＥＮＡＮＡhA5rKRv12L
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1067Please respect copyright.ＰＥＮＡＮＡ9yrOkcNLBQ
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1067Please respect copyright.ＰＥＮＡＮＡ0nXzurYLGs
1067Please respect copyright.ＰＥＮＡＮＡ0ABcwQQRZN
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1067Please respect copyright.ＰＥＮＡＮＡCFbWmbqlND
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Link:1067Please respect copyright.ＰＥＮＡＮＡzuFCfT0655
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1067Please respect copyright.ＰＥＮＡＮＡ2i2HaRFMgj
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1067Please respect copyright.ＰＥＮＡＮＡrv3XX1nML4
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1067Please respect copyright.ＰＥＮＡＮＡjNwAD9GrpR
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661067Please respect copyright.ＰＥＮＡＮＡKLooTp7NfV
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1067Please respect copyright.ＰＥＮＡＮＡULTSwE8qX0
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1067Please respect copyright.ＰＥＮＡＮＡrmPK9w55rM
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1067Please respect copyright.ＰＥＮＡＮＡOS3BYwmSb9
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