此為上集的補充篇:三十秒科學–癌症所導致的體重流失501Please respect copyright.PENANATc9ne63t0T
https://lih.kg/2397914501Please respect copyright.PENANAs0ShavwfRP
501Please respect copyright.PENANAFg4W8Rc0vW
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失,大部份情況下主要是由喪失肌肉所致,並沒法依靠進食來填補其喪失。501Please respect copyright.PENANA3wbbcPHouh501Please respect copyright.PENANAT68JkeV1Rf
501Please respect copyright.PENANAgBv7x9lRK0
在眾多癌症之中,高達接近70%的胰臟癌病人會出現cancer cachexia,總體重的損失在六個月內可高達25%。501Please respect copyright.PENANAo3H7B163nN
相反,患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。501Please respect copyright.PENANAU903FYVq8I
501Please respect copyright.PENANAOYHCPH7Jrd
501Please respect copyright.PENANA1sECBiEYmg
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標),其生存的機率亦會因而顯著下降。501Please respect copyright.PENANAzHxJA1exLc501Please respect copyright.PENANA2LBbGajUzd
501Please respect copyright.PENANAnQW4BKw60u
正因如此,若能了解其cancer cachexia機制並加以針對的話,將會是抵抗癌症的其中一道手法。501Please respect copyright.PENANAnuxMb2F6YI
501Please respect copyright.PENANA6iTcIVDKP8
501Please respect copyright.PENANAeMAiza99XL
(圖3)癌細胞所導致的體重流失,主要是由肌肉喪失所致。501Please respect copyright.PENANAucDnZja7Ru
而當我們的肌肉受到傷害或撕裂的時候,裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉,填補其損失。501Please respect copyright.PENANALRFqzsBcav501Please respect copyright.PENANAn1FFl1Eqht
501Please respect copyright.PENANAkG1kAZZ2nd
501Please respect copyright.PENANALww3Y6LiZi
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉,誘導肌肉出現受傷情況之餘,並同時阻止肌肉幹細胞進行重生,因而導致肌肉流失情況發生。501Please respect copyright.PENANAVd6Javj6lq
501Please respect copyright.PENANAzmpyC4bAzk
癌細胞之所以這樣做,其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加,然後借助肝臟把這些氨基酸轉變成糖份,再由血液循環系統輸送給自身所用。501Please respect copyright.PENANA9IQ33fS6gQ
501Please respect copyright.PENANAYaYi7IkBtu
因著胰臟癌病人出現cancer cachexia的機率較高,有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。501Please respect copyright.PENANA8nDb16W24N
501Please respect copyright.PENANAQCAsrLmljo
至今已至少找出得到,癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升,並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。501Please respect copyright.PENANADy8sNcztZq
501Please respect copyright.PENANARAQH1Ap4pF
501Please respect copyright.PENANAzjjkwgwb4i
501Please respect copyright.PENANActRgLfRQ6k
501Please respect copyright.PENANAzUwI4JkQCM
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。501Please respect copyright.PENANADjFgc2aYGP
501Please respect copyright.PENANAsOnzQ5mRu2
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc501Please respect copyright.PENANA9ep5G1YBZT
501Please respect copyright.PENANAjaU9BNBZi2
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。501Please respect copyright.PENANAzgUMmy52Yt
501Please respect copyright.PENANAcsPUmDJhNM
Link:501Please respect copyright.PENANAvXe9nw8LDp
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio501Please respect copyright.PENANA9ymLOOzyt1
501Please respect copyright.PENANAm10N0BKNxR
501Please respect copyright.PENANAAdpxWpBqnY
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。501Please respect copyright.PENANAIriGQ6QMFV
501Please respect copyright.PENANA31pT4TKQg5
Ref1:https://www.nature.com/articles/nrdp2017105501Please respect copyright.PENANAuAwJp47533