肌肉大概佔據身體重量的40%。438Please respect copyright.PENANAJOkjOH1Ngb438Please respect copyright.PENANAmX4oaw2XZC
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。438Please respect copyright.PENANA6I5vqgicEX
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。438Please respect copyright.PENANAuWYCidMD1v438Please respect copyright.PENANAk41jLDkfy2
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。438Please respect copyright.PENANAkWUK3y5sVs
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。438Please respect copyright.PENANAtVsEvyxgzE
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。438Please respect copyright.PENANAY8l9rgM6lr438Please respect copyright.PENANAOSvEwRO1fg
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。438Please respect copyright.PENANAwkVg18ZqBs
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。438Please respect copyright.PENANApV4o2zrWbl
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。438Please respect copyright.PENANAVMT9Ajq5Qv
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。438Please respect copyright.PENANAA7kr4lf9Uc
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。438Please respect copyright.PENANA0Jcb5SY49y
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。438Please respect copyright.PENANAjQaNctHblp
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio438Please respect copyright.PENANA2Oz1tR2hS1
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。438Please respect copyright.PENANA2rpmGp8vs6
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059438Please respect copyright.PENANALiZvWu1m4S