現今至少有兩間公司的人造抗體(LY/REGN)被緊急認可為武肺的治療方法。622Please respect copyright.PENANApSP8KDgX9L622Please respect copyright.PENANAbQklMgTiUv
622Please respect copyright.PENANApvsoMpTVP7
但基於這兩種人造抗體需經由血管注射,其間病人需卧床約一小時間,且需求人手密切監察整個過程,實際運行的成本非常高昂,因此未能普及。622Please respect copyright.PENANAkZ98SI9498
622Please respect copyright.PENANAI1kIRGrQF2
更甚的是,有數據顯示當人造抗體經血管注射後,能抵達肺部裡頭的數量少至有少(血液抗體含量比肺部抗體含量高出200-500倍有多),且已知當今的武肺病毒變種能有效躲避兩間公司的人造抗體追捕,使至人造抗體的地位日漸式微。622Please respect copyright.PENANAyARtuczklK
622Please respect copyright.PENANAVinSvYmsNl
622Please respect copyright.PENANAvojTvNg8ae
(圖2)武肺病毒最主要的作惡地方是肺部,要解決肺部抗體含量過少的問題,其中一道手段就是從鼻腔注射人造抗體,使其能較易直達肺部。622Please respect copyright.PENANAFQNPLmE4Tr622Please respect copyright.PENANAe29rd8gmvl
622Please respect copyright.PENANANmSIcKkPnz
從老鼠模型實驗中,可以見到往鼻腔注射人造抗體後,抗體(紅黃色區域)會聚集在鼻腔(N)及肺部(Lu)裡頭。622Please respect copyright.PENANAx8BuWQeLcG
622Please respect copyright.PENANAlWHVeNiF0H
622Please respect copyright.PENANACw8Pa3b5Ez
(圖3)至於解決武肺變種的問題,其中一手段就是將五個單一抗體連結成一個個體(五合一),利用「龐大」的身驅阻礙病毒進入細胞。622Please respect copyright.PENANAAzPvqV6QVG622Please respect copyright.PENANAXk3jtwae20
622Please respect copyright.PENANASmKBZ65bGC
在老鼠實驗中,鼻噴式的五合一抗體能有效阻隔英國及巴西變種等病毒,且有著預防及治療武肺的功效,同時亦沒有對老鼠的體重和明顯特徵做成任何影響。622Please respect copyright.PENANA0dOk8kdjeO
622Please respect copyright.PENANAhbeNPiYyVK
若能順利通過人體臨床實驗,定必為世界的安定起來重要的作用。622Please respect copyright.PENANA2UpTfcljC2
622Please respect copyright.PENANADyPkjhftl4
622Please respect copyright.PENANA48PKYYPyu6
622Please respect copyright.PENANA3z61LAwuNP
622Please respect copyright.PENANAxYovfszhPN
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。622Please respect copyright.PENANAksVsqLgJSz
622Please respect copyright.PENANAD80V9Wox6S
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc622Please respect copyright.PENANAQmaVIRiSgb
622Please respect copyright.PENANAzOyAZrl1NJ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。622Please respect copyright.PENANApvdKp0nR96
622Please respect copyright.PENANAffdf4Rv23Y
Link:622Please respect copyright.PENANAcFE6ISCUxL
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio622Please respect copyright.PENANA6z5W3SsPJR
622Please respect copyright.PENANAUp9IBfAw7D
622Please respect copyright.PENANAEEjaPJlLaF
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。622Please respect copyright.PENANAzQS1Szz9rY
622Please respect copyright.PENANAQVoT3RoBR0
Ref1:https://www.nature.com/articles/s41586-021-03673-2_reference.pdf622Please respect copyright.PENANANEWPmUTCfG