此篇文章並非意圖貶損任何癌症的治療方法,純粹是轉述一宗失敗個案及其原因,探討從失敗中學習的過程。519Please respect copyright.PENANAFmcZYAV5hP
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利用免疫治療法來對抗癌症,早前我們已經花了不少篇幅講述。519Please respect copyright.PENANAnJ69xPjYq7
延伸閱讀:https://www.penana.com/article/500206519Please respect copyright.PENANAQPFiVnpX9g519Please respect copyright.PENANAiq69Ygn86N
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CAR T cell治療法,就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件,引導它們更有效率殲滅對應的細胞;519Please respect copyright.PENANA1C1wA4Fsyn
在這個層面上,亦即是癌細胞。519Please respect copyright.PENANAceh5y0jTQ0
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(圖2)2010年,一名39歲女士患上腸癌,久經不同款式化療亦未見成效,故此便嘗試當時候較為新穎的CAR T cell 療法。519Please respect copyright.PENANAKnMcj4HqSM519Please respect copyright.PENANAfujb3u2qSd
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她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質,所以其治療的方式便是從她身上取得免疫細胞,再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell,再以將這些CAR T cell注入她體內,盼望這些CAR T cell會殲滅腸癌細胞。519Please respect copyright.PENANAM4gZwSs0sA
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(圖3)不幸的是,注入CAR T cell後的15分鐘,她出現呼吸困難等症狀,隨之亦送入ICU作出治療,唯5日後亦與世祥辭。519Please respect copyright.PENANAJYv2xWbx1R519Please respect copyright.PENANAB92FrhvT5v
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最後經驗屍及分析各種數據後,相信是因為肺部含有微量ERBB2蛋白質,在抵達癌細胞位置前,那些CAR T cell率先與持有ERBB2的肺部細胞結合,產生過量的免疫反應,引致肺部器官發炎及衰竭,導致氧氣沒能輸送至各器官位置。519Please respect copyright.PENANA3DoSlhO32S
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在這手術進行之前,亦有不少針對ERBB2的CAR T cell人體試驗,箇中並沒有發生相同症狀。519Please respect copyright.PENANA4qHu3anB3f
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這相信是因為是次手術為了希望能夠順利殲滅癌細胞,其注入的T cell數量被以往實驗過多,因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。519Please respect copyright.PENANA84AKiC0eHC
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無論如何,從這之經驗中可得知,ERBB2顯然並不是一道針對癌細胞的理想對象。519Please respect copyright.PENANAxbvPH8AWIs
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc519Please respect copyright.PENANAFNZsQtBwbv
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。519Please respect copyright.PENANAZYEPP74ySJ
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio519Please respect copyright.PENANApCj4duafNe
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。519Please respect copyright.PENANArpjUak2aUT
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Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
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