此篇文章並非意圖貶損任何癌症的治療方法，純粹是轉述一宗失敗個案及其原因，探討從失敗中學習的過程。519Please respect copyright.ＰＥＮＡＮＡFmcZYAV5hP
519Please respect copyright.ＰＥＮＡＮＡ0l7m8aVAF5
利用免疫治療法來對抗癌症，早前我們已經花了不少篇幅講述。519Please respect copyright.ＰＥＮＡＮＡnJ69xPjYq7
延伸閱讀:https://www.penana.com/article/500206519Please respect copyright.ＰＥＮＡＮＡQPFiVnpX9g
519Please respect copyright.ＰＥＮＡＮＡiq69Ygn86N
519Please respect copyright.ＰＥＮＡＮＡfgZmp9rMfm
CAR T cell治療法，就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件，引導它們更有效率殲滅對應的細胞;519Please respect copyright.ＰＥＮＡＮＡ1C1wA4Fsyn
在這個層面上，亦即是癌細胞。519Please respect copyright.ＰＥＮＡＮＡceh5y0jTQ0
519Please respect copyright.ＰＥＮＡＮＡhZFValNDvr
(圖2)2010年，一名39歲女士患上腸癌，久經不同款式化療亦未見成效，故此便嘗試當時候較為新穎的CAR T cell 療法。519Please respect copyright.ＰＥＮＡＮＡKnMcj4HqSM
519Please respect copyright.ＰＥＮＡＮＡfujb3u2qSd
519Please respect copyright.ＰＥＮＡＮＡMx3o6DyvIn
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質，所以其治療的方式便是從她身上取得免疫細胞，再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell，再以將這些CAR T cell注入她體內，盼望這些CAR T cell會殲滅腸癌細胞。519Please respect copyright.ＰＥＮＡＮＡM4gZwSs0sA
519Please respect copyright.ＰＥＮＡＮＡcqD5cCMkx7
519Please respect copyright.ＰＥＮＡＮＡViBs8DNp7V
(圖3)不幸的是，注入CAR T cell後的15分鐘，她出現呼吸困難等症狀，隨之亦送入ICU作出治療，唯5日後亦與世祥辭。519Please respect copyright.ＰＥＮＡＮＡJYv2xWbx1R
519Please respect copyright.ＰＥＮＡＮＡB92FrhvT5v
519Please respect copyright.ＰＥＮＡＮＡIW7HHS17OR
最後經驗屍及分析各種數據後，相信是因為肺部含有微量ERBB2蛋白質，在抵達癌細胞位置前，那些CAR T cell率先與持有ERBB2的肺部細胞結合，產生過量的免疫反應，引致肺部器官發炎及衰竭，導致氧氣沒能輸送至各器官位置。519Please respect copyright.ＰＥＮＡＮＡ3DoSlhO32S
519Please respect copyright.ＰＥＮＡＮＡR3Hxam9in9
在這手術進行之前，亦有不少針對ERBB2的CAR T cell人體試驗，箇中並沒有發生相同症狀。519Please respect copyright.ＰＥＮＡＮＡ4qHu3anB3f
519Please respect copyright.ＰＥＮＡＮＡLk8JJGorbw
這相信是因為是次手術為了希望能夠順利殲滅癌細胞，其注入的T cell數量被以往實驗過多，因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。519Please respect copyright.ＰＥＮＡＮＡ84AKiC0eHC
519Please respect copyright.ＰＥＮＡＮＡZ9mWDh5aW5
無論如何，從這之經驗中可得知，ERBB2顯然並不是一道針對癌細胞的理想對象。519Please respect copyright.ＰＥＮＡＮＡxbvPH8AWIs
519Please respect copyright.ＰＥＮＡＮＡWBSSQZeJs7
519Please respect copyright.ＰＥＮＡＮＡzgpPaRUu5C
519Please respect copyright.ＰＥＮＡＮＡnq6be9HjIo
519Please respect copyright.ＰＥＮＡＮＡ90U5vOECdi
519Please respect copyright.ＰＥＮＡＮＡyKbuvS9RcS
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。519Please respect copyright.ＰＥＮＡＮＡDzjnXe29R0
519Please respect copyright.ＰＥＮＡＮＡB1dTlX80G0
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc519Please respect copyright.ＰＥＮＡＮＡFNZsQtBwbv
519Please respect copyright.ＰＥＮＡＮＡJtzCNbSuOU
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。519Please respect copyright.ＰＥＮＡＮＡZYEPP74ySJ
519Please respect copyright.ＰＥＮＡＮＡS2KTbNEKy1
Link:519Please respect copyright.ＰＥＮＡＮＡ3WJnxGEn25
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio519Please respect copyright.ＰＥＮＡＮＡpCj4duafNe
519Please respect copyright.ＰＥＮＡＮＡiamHbb3ubL
519Please respect copyright.ＰＥＮＡＮＡS8QF4yI6m5
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。519Please respect copyright.ＰＥＮＡＮＡrpjUak2aUT
519Please respect copyright.ＰＥＮＡＮＡoHjCyFk9wV
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
519Please respect copyright.ＰＥＮＡＮＡf7qTOwslkW
