此篇文章並非意圖貶損任何癌症的治療方法,純粹是轉述一宗失敗個案及其原因,探討從失敗中學習的過程。517Please respect copyright.PENANArN2syhvYra
517Please respect copyright.PENANAaw328XafBa
利用免疫治療法來對抗癌症,早前我們已經花了不少篇幅講述。517Please respect copyright.PENANApn6ppDVJrp
延伸閱讀:https://www.penana.com/article/500206517Please respect copyright.PENANAEQdCU6L2Dm517Please respect copyright.PENANAjEX55CVWmY
517Please respect copyright.PENANAxH4B3oe7tS
CAR T cell治療法,就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件,引導它們更有效率殲滅對應的細胞;517Please respect copyright.PENANAfSbR9AmaIg
在這個層面上,亦即是癌細胞。517Please respect copyright.PENANAR5lXjwGyIw
517Please respect copyright.PENANANavYQ3emue
(圖2)2010年,一名39歲女士患上腸癌,久經不同款式化療亦未見成效,故此便嘗試當時候較為新穎的CAR T cell 療法。517Please respect copyright.PENANA59UfSYcIM3517Please respect copyright.PENANAa9MipsUxj5
517Please respect copyright.PENANAjMks28gtKE
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質,所以其治療的方式便是從她身上取得免疫細胞,再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell,再以將這些CAR T cell注入她體內,盼望這些CAR T cell會殲滅腸癌細胞。517Please respect copyright.PENANAXRpurEZ0MD
517Please respect copyright.PENANACPIstEah9m
517Please respect copyright.PENANAalgJFLifYt
(圖3)不幸的是,注入CAR T cell後的15分鐘,她出現呼吸困難等症狀,隨之亦送入ICU作出治療,唯5日後亦與世祥辭。517Please respect copyright.PENANAxP7Xj8jmZf517Please respect copyright.PENANA3i0V6W1uPq
517Please respect copyright.PENANA0ZQtAU7tZi
最後經驗屍及分析各種數據後,相信是因為肺部含有微量ERBB2蛋白質,在抵達癌細胞位置前,那些CAR T cell率先與持有ERBB2的肺部細胞結合,產生過量的免疫反應,引致肺部器官發炎及衰竭,導致氧氣沒能輸送至各器官位置。517Please respect copyright.PENANA2JfwI1SEQU
517Please respect copyright.PENANA7s3lpAqpUE
在這手術進行之前,亦有不少針對ERBB2的CAR T cell人體試驗,箇中並沒有發生相同症狀。517Please respect copyright.PENANAVKK2ajcmZR
517Please respect copyright.PENANAy1mZ72EVDX
這相信是因為是次手術為了希望能夠順利殲滅癌細胞,其注入的T cell數量被以往實驗過多,因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。517Please respect copyright.PENANA6Jm4qJisaw
517Please respect copyright.PENANAQQLg7LWoEx
無論如何,從這之經驗中可得知,ERBB2顯然並不是一道針對癌細胞的理想對象。517Please respect copyright.PENANAjDvjxKKQG1
517Please respect copyright.PENANAyyFeDrEQze
517Please respect copyright.PENANAZWFPm10jx1
517Please respect copyright.PENANAGajPejfkkb
517Please respect copyright.PENANA2bXJNrUQiT
517Please respect copyright.PENANAmkiY3bzXdg
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。517Please respect copyright.PENANAflsHAgNrB1
517Please respect copyright.PENANAX8TmwEvzBr
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc517Please respect copyright.PENANAfMA4pMAWUu
517Please respect copyright.PENANA9bYoghGTXJ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。517Please respect copyright.PENANAWONRjeeK9l
517Please respect copyright.PENANAA8dXKN6ord
Link:517Please respect copyright.PENANAoswFgiZpmn
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio517Please respect copyright.PENANAMsmdjNBGZ4
517Please respect copyright.PENANAJEt4zUU094
517Please respect copyright.PENANAPf570rdZ0Q
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。517Please respect copyright.PENANAi1HeW8wF83
517Please respect copyright.PENANASfsNuWO0YD
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
517Please respect copyright.PENANAn8uKAdbQ6A