此為上集的補充篇:三十秒科學–癌症所導致的體重流失405Please respect copyright.PENANAmBUPzgBYIg
https://lih.kg/2397914405Please respect copyright.PENANAHvlBk9m3s7
405Please respect copyright.PENANAnAFsMEBcyP
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失,大部份情況下主要是由喪失肌肉所致,並沒法依靠進食來填補其喪失。405Please respect copyright.PENANAdvU3IYDp7I405Please respect copyright.PENANAOGrPC4zKfG
405Please respect copyright.PENANADkV2Ujmsog
在眾多癌症之中,高達接近70%的胰臟癌病人會出現cancer cachexia,總體重的損失在六個月內可高達25%。405Please respect copyright.PENANANS9Zx6qKTV
相反,患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。405Please respect copyright.PENANADQsiBlv1YT
405Please respect copyright.PENANAwZWZ39Lvpc
405Please respect copyright.PENANAFhELfAUE9W
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標),其生存的機率亦會因而顯著下降。405Please respect copyright.PENANAJ7KFBEz0mZ405Please respect copyright.PENANAgt3jtOoY04
405Please respect copyright.PENANAKE7hBuI2HP
正因如此,若能了解其cancer cachexia機制並加以針對的話,將會是抵抗癌症的其中一道手法。405Please respect copyright.PENANAUqmLtYuYA2
405Please respect copyright.PENANAqNZezcCKz7
405Please respect copyright.PENANARZ0OgKFrfO
(圖3)癌細胞所導致的體重流失,主要是由肌肉喪失所致。405Please respect copyright.PENANAILdCgxoXwS
而當我們的肌肉受到傷害或撕裂的時候,裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉,填補其損失。405Please respect copyright.PENANAqL9qmIbgDI405Please respect copyright.PENANAMoAOxR6ANI
405Please respect copyright.PENANAuSEQnBunWW
405Please respect copyright.PENANA8V5VYVrqOs
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉,誘導肌肉出現受傷情況之餘,並同時阻止肌肉幹細胞進行重生,因而導致肌肉流失情況發生。405Please respect copyright.PENANAyhozZfgbTY
405Please respect copyright.PENANAnEeqYXJA6r
癌細胞之所以這樣做,其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加,然後借助肝臟把這些氨基酸轉變成糖份,再由血液循環系統輸送給自身所用。405Please respect copyright.PENANApkF9Wav72g
405Please respect copyright.PENANAA56xfldqm7
因著胰臟癌病人出現cancer cachexia的機率較高,有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。405Please respect copyright.PENANA9lBrJAWiLB
405Please respect copyright.PENANAicibrV6DXH
至今已至少找出得到,癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升,並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。405Please respect copyright.PENANADxCxRBYCfR
405Please respect copyright.PENANAIRKnQwzYXy
405Please respect copyright.PENANAGKYFH0fSoa
405Please respect copyright.PENANAMOjCnEET4h
405Please respect copyright.PENANAmSxgODBo4V
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。405Please respect copyright.PENANA4qDYPV1fgV
405Please respect copyright.PENANAcc5QLYRmmN
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc405Please respect copyright.PENANA9ot3ExsUHX
405Please respect copyright.PENANAzrlhAuOBT9
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。405Please respect copyright.PENANA7FPoVnDql9
405Please respect copyright.PENANAv9R7rAbTKu
Link:405Please respect copyright.PENANA5ZOqB3aSvR
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio405Please respect copyright.PENANAuFcEYPb1XR
405Please respect copyright.PENANA4fIgRJzdgc
405Please respect copyright.PENANADUYIgZnHTL
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。405Please respect copyright.PENANA31NdlOy5ai
405Please respect copyright.PENANAu76A7KU2yj
Ref1:https://www.nature.com/articles/nrdp2017105405Please respect copyright.PENANAVPYen8cSBT