上集略述了心臟肥大與心臟衰竭的關連,今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。522Please respect copyright.PENANAa6ovZTjlC9522Please respect copyright.PENANAhYg7bunhBY
522Please respect copyright.PENANA01iYnmZeu6
上集:https://lih.kg/gOrCdS522Please respect copyright.PENANAhFkC9urMLf
522Please respect copyright.PENANAAmHZxSKc0e
(圖2)研究發現,當利用縫線手法引致心臟處於肥大狀態的時候,一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。522Please respect copyright.PENANAOKIMt3Ql41522Please respect copyright.PENANAr7W9pjvNvo
522Please respect copyright.PENANAZ4ocEnhgrM
522Please respect copyright.PENANAYsJoIsUkwu
(圖3)當GRK5進入細胞核後,它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動,因而改變其自身的形狀,發揮一系列的功效引致心臟肥大。522Please respect copyright.PENANAiqG87K80XZ522Please respect copyright.PENANA2B6y4puKv4
522Please respect copyright.PENANAC9jXoacaBB
見狀,科學家便特意單獨注入其紅色部份到細胞核,目的就是想透過紅色部份的霸佔,阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動,使其功效喪失。522Please respect copyright.PENANAxh8cJOemG5
522Please respect copyright.PENANAMfOFK5Az5v
形象化來說,就是某勢力派人霸佔旁聽座位,讓其他人士無法入座。522Please respect copyright.PENANAJSazBbRPsA
522Please respect copyright.PENANA378kdaDMqd
522Please respect copyright.PENANAx02ZQ1tWTd
(圖4)縫線後所引起的心臟肥大,並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。522Please respect copyright.PENANADxKOlStOju522Please respect copyright.PENANAUrhMeRXtEk
522Please respect copyright.PENANAt2b7kM87T7
最為重要的是,心臟肥大所引起的心肌纖維化(藍色箭嘴),並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。522Please respect copyright.PENANAzm7mFDB85z
522Please respect copyright.PENANArE2dkD6QTs
522Please respect copyright.PENANAgAqouwyonX
換句話說,這GRK5的紅色部份,非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。522Please respect copyright.PENANAz8X5ZFyTJu
522Please respect copyright.PENANAO5STAp9SDU
522Please respect copyright.PENANAXXeI4JWVHl
522Please respect copyright.PENANAR2jYPCCipE
522Please respect copyright.PENANAEha2j2YOrv
522Please respect copyright.PENANAzhymZEcwwz
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。522Please respect copyright.PENANASMbrSxTyC9
522Please respect copyright.PENANAS4KnCitdLa
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc522Please respect copyright.PENANACDFBmRg1w6
522Please respect copyright.PENANAkjufnE7xgx
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。522Please respect copyright.PENANAodCYN4wKTj
522Please respect copyright.PENANAF3Q5rqICQ1
Link:522Please respect copyright.PENANApMlNXWo0LM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio522Please respect copyright.PENANAG07gioViBS
522Please respect copyright.PENANAqBJZQ2NmUD
522Please respect copyright.PENANAO75WGPUje3
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。522Please respect copyright.PENANA320Tn5Pk5T
522Please respect copyright.PENANA6DOIwPlYKI
Ref1:https://stke.sciencemag.org/content/14/676/eabb5968522Please respect copyright.PENANAfmmm1Nz0cK