上兩集簡述了癌細胞缺氧的成因，以及缺氧導致癌細胞相對上更為依賴葡萄糖作新陳代謝用途。578Please respect copyright.ＰＥＮＡＮＡWlQFPM4rcs
578Please respect copyright.ＰＥＮＡＮＡOUAM4bDy87
578Please respect copyright.ＰＥＮＡＮＡqAc3is6lo0
三十秒科學–腫瘤的周遭環境578Please respect copyright.ＰＥＮＡＮＡtzTOy693wH
https://lih.kg/gFPfPS578Please respect copyright.ＰＥＮＡＮＡm6gAmztDPu
578Please respect copyright.ＰＥＮＡＮＡJqJWEqLmvq
三十秒科學–癌細胞嗜糖的原因578Please respect copyright.ＰＥＮＡＮＡ2Q7btXFbMe
https://lih.kg/2416199578Please respect copyright.ＰＥＮＡＮＡFZTmulOgKn
578Please respect copyright.ＰＥＮＡＮＡhcdv8oMa0M
今集我們會講述缺氧對癌細胞自身發展的其中一道好處。578Please respect copyright.ＰＥＮＡＮＡ42XJrfaJe2
578Please respect copyright.ＰＥＮＡＮＡgGiOMkWecB
（圖2）當DNA出現異變的時候，細胞裡名為p53的蛋白質便會出手幫忙，號令細胞停止生長(Cell cycle arrest)，給予時間讓其他蛋白質幫忙協助修復DNA。578Please respect copyright.ＰＥＮＡＮＡsIsljM8j8C
578Please respect copyright.ＰＥＮＡＮＡxfL3L8zQYK
578Please respect copyright.ＰＥＮＡＮＡibZe54ZmiH
若果細胞最後還是無法處理修復DNA的工作，p53便會指示細胞趨向死亡程序(Apoptosis)。578Please respect copyright.ＰＥＮＡＮＡEfytz4QCPV
578Please respect copyright.ＰＥＮＡＮＡmblXwE2qmA
腫瘤的出現，是無數DNA變異得出來的成果。因此在這方面來看，p53是防止癌細胞出現的好幫手，因為p53會確保細胞的DNA不會出現變異，或指令出現DNA變異的細胞消失。578Please respect copyright.ＰＥＮＡＮＡSuicgEo8bX
578Please respect copyright.ＰＥＮＡＮＡ8WG5VUyM3p
但是，有一點非常矛盾的是，大部份普通細胞的p53蛋白質表達率非常低，它能否防止癌細胞出現這一點使人存疑。578Please respect copyright.ＰＥＮＡＮＡAJYnWsH1ou
578Please respect copyright.ＰＥＮＡＮＡ7Qaclmq1Zl
（圖3）事實上，非常諷刺的是，氧氣含量越低的話，P53蛋白質的表達率便會越高。578Please respect copyright.ＰＥＮＡＮＡLuFROq6oOp
578Please respect copyright.ＰＥＮＡＮＡQKmFgK6sjW
578Please respect copyright.ＰＥＮＡＮＡLBMcgN9JWP
而在缺氧的環境下，擁有p53的蛋白質的細胞便會自動進行死亡。578Please respect copyright.ＰＥＮＡＮＡXRBr3jRs2p
578Please respect copyright.ＰＥＮＡＮＡ4d0tQ911s6
（圖4）重大的問題是，有部份缺氧的癌細胞會發展出變異版本的p53，失去原有的功能。578Please respect copyright.ＰＥＮＡＮＡhBgHyORy6B
在缺氧施加的壓力下，擁有正常p53版本的細胞會一一死去，變相幫忙篩選出擁有變異版本p53的細胞，使它們逐漸成為大多數。578Please respect copyright.ＰＥＮＡＮＡeqrJ14YnPu
578Please respect copyright.ＰＥＮＡＮＡelvoEeRxbP
578Please respect copyright.ＰＥＮＡＮＡoAJRJRTkof
而這些擁有變異版本p53的細胞，修復DNA的能力會大幅度被削弱，因而加劇了DNA變異速度，促成腫瘤繼續長大。578Please respect copyright.ＰＥＮＡＮＡ1hwxa0yX9k
578Please respect copyright.ＰＥＮＡＮＡoRn5njhTDL
（圖5）圖中為腫瘤形成的其中一道概論，癌細胞自製的缺氧環境，變相提供了一道挑選擁有更強DNA變異能力細胞的環境。578Please respect copyright.ＰＥＮＡＮＡWJy4xeSjEi
578Please respect copyright.ＰＥＮＡＮＡ88EbXMMfW8
578Please respect copyright.ＰＥＮＡＮＡRWOf3gIyZO
現實中大部分的的癌細胞均擁有p53變異，而擁有p53變異的細胞更具抵抗化療藥物cis-platin的能力。578Please respect copyright.ＰＥＮＡＮＡox8SPhLabb
578Please respect copyright.ＰＥＮＡＮＡma5ivhsLw1
除缺氧外，大陽的紫外光亦是促使p53變異的好幫手，不少皮膚癌細胞均出現至少一處的p53變異。578Please respect copyright.ＰＥＮＡＮＡbVanfiv8qV
578Please respect copyright.ＰＥＮＡＮＡ3i9kUzda0E
那些不塗防曬便與陽光玩遊戲的人，一直是在玩命。578Please respect copyright.ＰＥＮＡＮＡEv7vivgvru
578Please respect copyright.ＰＥＮＡＮＡtyHusffwEb
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。578Please respect copyright.ＰＥＮＡＮＡWg3QiuD0AQ
578Please respect copyright.ＰＥＮＡＮＡ6oWOvwxkrk
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc578Please respect copyright.ＰＥＮＡＮＡU1U4hiNWby
578Please respect copyright.ＰＥＮＡＮＡE99m5P8XOM
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。578Please respect copyright.ＰＥＮＡＮＡSyY29JPrbo
578Please respect copyright.ＰＥＮＡＮＡmBvIvvT4P8
Link:578Please respect copyright.ＰＥＮＡＮＡw97duozFo9
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio578Please respect copyright.ＰＥＮＡＮＡYD1EyNAS0L
578Please respect copyright.ＰＥＮＡＮＡfIWscpgXXM
578Please respect copyright.ＰＥＮＡＮＡG5Q2V4Q1V4
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。578Please respect copyright.ＰＥＮＡＮＡuSAO6vdTsb
578Please respect copyright.ＰＥＮＡＮＡjQng6ZxBX5
Ref1:https://pubmed.ncbi.nlm.nih.gov/8538748/578Please respect copyright.ＰＥＮＡＮＡ201WIIPt6s
