肌肉大概佔據身體重量的40%。535Please respect copyright.PENANA3XKeUDdgd4535Please respect copyright.PENANAysk8vPHDRD
535Please respect copyright.PENANABZe7iE724u
踏入50歲後,平均每10年就會有15-30%的肌肉流失。535Please respect copyright.PENANADPjw8BK8wg
535Please respect copyright.PENANANI9UD0l6XJ
(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。535Please respect copyright.PENANAnC7P7hLYBL535Please respect copyright.PENANAVDMvUuOShC
535Please respect copyright.PENANAokxujit5K4
而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。535Please respect copyright.PENANAIr8ACS1p8T
535Please respect copyright.PENANA5OeXawYOAd
(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。535Please respect copyright.PENANApB5sTVZArU
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。535Please respect copyright.PENANAOpXrvwsOwW535Please respect copyright.PENANAnopQp4poX5
535Please respect copyright.PENANAfA90Ck8ewm
當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。535Please respect copyright.PENANAnfeJJdL30U
535Please respect copyright.PENANAUt4OBKpkQa
相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。535Please respect copyright.PENANADCyDBmqowE
535Please respect copyright.PENANAYgvA93Z34X
這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。535Please respect copyright.PENANA9xgnNeVqZw
535Please respect copyright.PENANAKgkQJ4gUHE
現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。535Please respect copyright.PENANA2g4cEuLmVQ
535Please respect copyright.PENANABfOrLVT1b6
只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。535Please respect copyright.PENANAsXkppZqVXr
535Please respect copyright.PENANA3Gfi6DGGw1
535Please respect copyright.PENANA8ewX4H3Vcc
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。535Please respect copyright.PENANACgqTuGfG0j
535Please respect copyright.PENANAfaBhZ9mc7o
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc535Please respect copyright.PENANAArMIQODuln
535Please respect copyright.PENANAKXVC4djVL9
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。535Please respect copyright.PENANAcIjjQocTnt
535Please respect copyright.PENANAlFo0tYSI7v
Link:535Please respect copyright.PENANA4bczE3oGR5
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio535Please respect copyright.PENANAVzcYKqa7QY
535Please respect copyright.PENANAAxugmHo8oL
535Please respect copyright.PENANAzjqarfbtW2
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。535Please respect copyright.PENANAMaDQLwndAI
535Please respect copyright.PENANAC3Xd7Kpi7R
Ref1:https://science.sciencemag.org/content/371/6528/eabc8059535Please respect copyright.PENANALGSW3OYwN6