化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?559Please respect copyright.PENANATosih4svG1559Please respect copyright.PENANAzmJu0GrC9N
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(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。559Please respect copyright.PENANAGyAZtLbZwN
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。559Please respect copyright.PENANA2WKPbBTNWg559Please respect copyright.PENANA70nSThUtF5
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如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。559Please respect copyright.PENANANvRm6LxwGZ
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。559Please respect copyright.PENANA3AD0EFP9X8
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(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。559Please respect copyright.PENANAuwkQOesurN559Please respect copyright.PENANAXhWwWeHQ8D
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(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。559Please respect copyright.PENANAtHPsgxFgrK559Please respect copyright.PENANAjIqiIveNqr
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但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。559Please respect copyright.PENANANv8p5OIU91
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並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。559Please respect copyright.PENANAdWgn9zGIZf
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若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。559Please respect copyright.PENANAuAZh8nKflY
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。559Please respect copyright.PENANAHCc5r1ad3E
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Link:559Please respect copyright.PENANAFXoUH3GTjt
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio559Please respect copyright.PENANABYHoQqoHax
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。559Please respect copyright.PENANAfhgLpIg518
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Ref1:https://www.nature.com/articles/s41467-020-14928-3559Please respect copyright.PENANAmY2Rkm6wtE