真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。626Please respect copyright.PENANAan83wXuokv626Please respect copyright.PENANA4SDqP7jewv
626Please respect copyright.PENANAs10vs9ztbS
(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。626Please respect copyright.PENANAaJ6Mhm8qFL626Please respect copyright.PENANAbOIwvnsogH
626Please respect copyright.PENANAvXHTutazKr
1.Azole626Please respect copyright.PENANArewkWdqxXL
抑制構成細胞膜的Ergosterol產生626Please respect copyright.PENANAhpPYgDwGsR
2. Polyene626Please respect copyright.PENANAtAV4kkT8kR
消耗細胞膜的Ergosterol626Please respect copyright.PENANAExjNnX1YWP
3. Echinocandins626Please respect copyright.PENANALxUhh4E7Bf
抑制構成細胞外層的糖分組織產生626Please respect copyright.PENANA2RjFP2h090
626Please respect copyright.PENANAdJ6PWNpysM
626Please respect copyright.PENANAQ0Rb3qLBZA
(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。626Please respect copyright.PENANAlz3zheI7Wt626Please respect copyright.PENANAwU9was64ef
626Please respect copyright.PENANALNzSVTp5yW
它能夠透過血液循環系統走進全身各部位,引發感染。626Please respect copyright.PENANArQgQ19CIMB
626Please respect copyright.PENANAYJDUXiSTUa
就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。626Please respect copyright.PENANAgOv5Uhxv6G
626Please respect copyright.PENANAkOfaRTgrkF
(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。626Please respect copyright.PENANAEfCCnri4mv626Please respect copyright.PENANACdWe6Pj63G
626Please respect copyright.PENANAmhCZYtKtym
Turbinmicin能有效抑制不同真菌品種,包括Candida auris。626Please respect copyright.PENANAzoprIkrpLo
626Please respect copyright.PENANAPe6PlxaJRu
它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。626Please respect copyright.PENANAx7uiOTYKsx
626Please respect copyright.PENANAjUDIJcflGv
它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。626Please respect copyright.PENANAxviE2tNODm
626Please respect copyright.PENANAeO6EjelzgJ
但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。626Please respect copyright.PENANAXpECTVT4uE
626Please respect copyright.PENANArqqOSZeMPr
626Please respect copyright.PENANAQQ3hd0mJLG
深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。626Please respect copyright.PENANAEOQDXLIByf
626Please respect copyright.PENANA713E4HdSP3
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。626Please respect copyright.PENANAhEuuggJdJ7
626Please respect copyright.PENANACzxFzN4D7M
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc626Please respect copyright.PENANArmwfj2ReUV
626Please respect copyright.PENANAt5cWx4pCAX
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。626Please respect copyright.PENANABBpkogturS
626Please respect copyright.PENANAAi1QGRynA4
Link:626Please respect copyright.PENANAVIrDK8MRJi
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio626Please respect copyright.PENANANq9yUJyJ2u
626Please respect copyright.PENANAeSon5lqAAx
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。626Please respect copyright.PENANADQ388CxLnK
626Please respect copyright.PENANAdd1EN10YOV
https://www.instagram.com/potatopigtongue/626Please respect copyright.PENANAWFYvP5s3MH
626Please respect copyright.PENANA6ByuY7Xc3e
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112626Please respect copyright.PENANAfhfgjkBwyR
Ref2:https://science.sciencemag.org/content/370/6519/974626Please respect copyright.PENANAqYbpifaEjt