隨著細胞的基因變異一直累積,正常細胞形成癌細胞的機會亦會相應提升。543Please respect copyright.PENANABBBwV5WP5D
543Please respect copyright.PENANAIRRS0HVFJR
但細胞是否只需要基因變異這一個誘因便能夠轉化為癌細胞呢?543Please respect copyright.PENANAzOxeQ7TcJz
543Please respect copyright.PENANACabMMWsPy9
這一方面還有一定程度的斟酌空間。543Please respect copyright.PENANAGSN8ghmk5o543Please respect copyright.PENANAVS0JhXoDAO
543Please respect copyright.PENANAqgQLr7Zcly
舉例來說,NOTCH1基因變異被認定為是推進食道細胞轉化成為癌細胞的其中一個原因。543Please respect copyright.PENANA2gtzRInw2z
543Please respect copyright.PENANAmyzs1TumKf
但在長者的健康食道細胞裡頭,約有30-80%的細胞均擁有NOTCH1基因變異,而他們身體並沒有出現及發生食道癌。543Please respect copyright.PENANAMs5AgGEP7W
543Please respect copyright.PENANAkIsGIjhpiU
543Please respect copyright.PENANAIB9zNfNmaQ
(圖2)而在老鼠實驗方面,單憑服用DMBA (引致Hras基因變異)或Croton oil(引致發炎效用,不會促進基因變異)的話,並不會引起癌細胞的出現。543Please respect copyright.PENANAI1adwG7hGk
543Please respect copyright.PENANAmiUgFUFWvm
唯獨兩者以先後的方式給予老鼠的話,癌細胞才會有所形成。543Please respect copyright.PENANANg6UVnQwsK543Please respect copyright.PENANAZPA8QS59kZ
543Please respect copyright.PENANA29Er7vW2Vd
543Please respect copyright.PENANAZnfaSV144O
這不禁讓科學家開始思考一道問題,是否基因變異再加上某種特定條件,就可以促進癌細胞形成呢?543Please respect copyright.PENANAzIFdHrzVjK
543Please respect copyright.PENANA0Yq8pfjVku
(圖3)為解答這個問題,英國開始了名為Mutographs的計劃,543Please respect copyright.PENANAdSUYNj3yQ9543Please respect copyright.PENANAvY1Dg6QGxq
543Please respect copyright.PENANA3DE1hIQQF0
集5大洲超過5000個病人的癌細胞基因圖譜(主要集中在食道、大腸、腎臟及胰臟癌),543Please respect copyright.PENANA7c1UlcP42d
543Please respect copyright.PENANATzChHTPQTt
同時比對病人的日常習慣(食用習慣、酒精飲用、熱飲喜好等等),543Please respect copyright.PENANAZnLTn4HMNG
543Please respect copyright.PENANAJP2iAZNBff
其中一個目標就是想找出哪一種特殊條件配上某一個基因變異會特別容易促進癌細胞的形成。543Please respect copyright.PENANAmgI4JZiB6d
543Please respect copyright.PENANAD4zSlEODZo
若然能得出確切的結果並附上內裡的細胞機制支持的話,這將會為預防癌症形成的領域作出重大的貢獻。543Please respect copyright.PENANAVwMNzVHukn
543Please respect copyright.PENANApazHlq2rPL
以上的資料均取自Ref1。543Please respect copyright.PENANALzUeoEPDf3
543Please respect copyright.PENANA5VKziwprAa
543Please respect copyright.PENANAODC8ns8TlJ
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。543Please respect copyright.PENANA7EYB6FX1hW
543Please respect copyright.PENANAMLBuM7GzXB
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc543Please respect copyright.PENANAMBlXnuYXsM
543Please respect copyright.PENANArEoiv63QOV
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。543Please respect copyright.PENANAdRzUXB1BPw
543Please respect copyright.PENANAGcL63ZNp3J
Link:543Please respect copyright.PENANArmMkOxoHYt
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio543Please respect copyright.PENANAmHjCUZuf6I
543Please respect copyright.PENANAwOB1wQj7ny
543Please respect copyright.PENANA8yGnNbNDNS
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。543Please respect copyright.PENANA16LWikEGFU
543Please respect copyright.PENANARY73LwAYGo
https://www.instagram.com/potatopigtongue/543Please respect copyright.PENANAGktrudJ9Pd
543Please respect copyright.PENANAtoYiOUiVAC
Ref1:https://www.nature.com/articles/s41588-020-00727-5
00
ns216.73.216.166da2