當細胞裡頭出現多餘或者已受損毀的物質，又或者是細胞面臨營養不足的情況，細胞便會啟動名為自噬(Autophagy)的機制，依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪，供自己能量或物質所需。613Please respect copyright.ＰＥＮＡＮＡZ4Reu35CXM
613Please respect copyright.ＰＥＮＡＮＡM1E3neazFZ
613Please respect copyright.ＰＥＮＡＮＡdVcrthiLhm
早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。613Please respect copyright.ＰＥＮＡＮＡKrjyzvIRei
三十秒科學–癌細胞也會自肥？613Please respect copyright.ＰＥＮＡＮＡXbkifGvjeO
- 分享自 LIHKG 討論區613Please respect copyright.ＰＥＮＡＮＡVgqX55Y5BG
https://lih.kg/hgfcNS613Please respect copyright.ＰＥＮＡＮＡ5AJBltwvYv
613Please respect copyright.ＰＥＮＡＮＡuXYA0TZ8LN
613Please respect copyright.ＰＥＮＡＮＡlk0df1aW5Z
(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質，使自己得以在困局下苟延殘喘。613Please respect copyright.ＰＥＮＡＮＡKkChDCTRjb
613Please respect copyright.ＰＥＮＡＮＡAqqj5rMEhd
613Please respect copyright.ＰＥＮＡＮＡcp0C1oUpSI
情形就如人們債務纏身而又沒有收入抵債的時候，只好變賣自己所持有的資產，化成現金抵償。613Please respect copyright.ＰＥＮＡＮＡaBHXWaZu6F
613Please respect copyright.ＰＥＮＡＮＡfVojmgDh5o
由此可以想像，這是一道治標不治標的方法。613Please respect copyright.ＰＥＮＡＮＡfPtw74HZKa
當長期沒有營養流入細胞，而細胞再也沒有多餘物質進行自噬的時候，細胞便會啟動自行滅亡的機制。613Please respect copyright.ＰＥＮＡＮＡrzUjSHTVMT
613Please respect copyright.ＰＥＮＡＮＡeIminwA4r9
613Please respect copyright.ＰＥＮＡＮＡ47qrlByhsa
(圖3)如果催谷癌細胞不斷進行自噬作用的話，促使它們啟動自行滅亡的機制，那豈不是殺滅它們的一道妙計?613Please respect copyright.ＰＥＮＡＮＡY1sJrm3llk
613Please respect copyright.ＰＥＮＡＮＡCDxC4rIA1O
613Please respect copyright.ＰＥＮＡＮＡqkK5TCDYk2
很遺憾地，各款癌細胞對於自噬作用的依賴及抗性均有所不同，難以就此單一針對自噬作用來消滅癌細胞。613Please respect copyright.ＰＥＮＡＮＡoCQZqNrezj
613Please respect copyright.ＰＥＮＡＮＡvF5aVdhCiW
暫時較為統一的發現是，大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。613Please respect copyright.ＰＥＮＡＮＡcEH8vdkYJb
613Please respect copyright.ＰＥＮＡＮＡwy6SLei3iN
在實驗室細胞模型及老鼠實驗中，若果對胰臟癌細胞使用抑制自噬作用的藥物，不但改變它們的新陳代謝，且可減慢癌細胞的生長速度，非常之有潛質成為對抗胰臟癌的其中一手段。613Please respect copyright.ＰＥＮＡＮＡ36p0PUTnfn
613Please respect copyright.ＰＥＮＡＮＡbVUWWjohli
613Please respect copyright.ＰＥＮＡＮＡuKLAsf72sh
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。613Please respect copyright.ＰＥＮＡＮＡGKyUlf63gb
613Please respect copyright.ＰＥＮＡＮＡsJgVSIYzcG
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc613Please respect copyright.ＰＥＮＡＮＡm3ZoFt2uBN
613Please respect copyright.ＰＥＮＡＮＡgK5N0rdNFv
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。613Please respect copyright.ＰＥＮＡＮＡZa980MGHlS
613Please respect copyright.ＰＥＮＡＮＡbMSd8G6VV7
Link:613Please respect copyright.ＰＥＮＡＮＡYvIaMhQTzS
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio613Please respect copyright.ＰＥＮＡＮＡj9ATliR4t8
613Please respect copyright.ＰＥＮＡＮＡCCyC0K22UV
613Please respect copyright.ＰＥＮＡＮＡ9c25003ET3
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。613Please respect copyright.ＰＥＮＡＮＡVWYNaF8H9i
613Please respect copyright.ＰＥＮＡＮＡsXsdnH7iu1
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/613Please respect copyright.ＰＥＮＡＮＡBGlDC3ewpg
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long
1
0
