近日有急凍雞翼及其他產品被測量出擁有武肺存在，但武肺能否在雞翼或其他食物上大量繁殖呢？917Please respect copyright.ＰＥＮＡＮＡtLMQKEkQDg
917Please respect copyright.ＰＥＮＡＮＡ8jNbUbEaLJ
答案是，不可以。917Please respect copyright.ＰＥＮＡＮＡVTPUiyKWMg
917Please respect copyright.ＰＥＮＡＮＡ19sbSVPZcJ
武肺進行大量繁殖的話，必需要借助活生生的細胞幫忙，而其中先決的一步就是要進入細胞體內。917Please respect copyright.ＰＥＮＡＮＡ7p3dSNa04C
917Please respect copyright.ＰＥＮＡＮＡm0tKWJqCKp
武肺可否入侵細胞，基本上視乎可唔可以達成下列3個條件。917Please respect copyright.ＰＥＮＡＮＡNFLRffk6SC
（圖1）917Please respect copyright.ＰＥＮＡＮＡ4KhQTwTNy6
917Please respect copyright.ＰＥＮＡＮＡa7d2ZfSMap
917Please respect copyright.ＰＥＮＡＮＡMGv7u368cw
1. S protein與細胞表面的ACE2觸碰。917Please respect copyright.ＰＥＮＡＮＡeEhAVZh2d5
917Please respect copyright.ＰＥＮＡＮＡ9ZQfbARfsb
2. 細胞表面ACE2與S protein的形狀吻合，亦即是「啱嘴形」。917Please respect copyright.ＰＥＮＡＮＡ9nqj59EaZ9
917Please respect copyright.ＰＥＮＡＮＡMzAXUGY1cP
3. 細胞表面擁有TMPRSS2蛋白質，能夠對S protein進行切割。917Please respect copyright.ＰＥＮＡＮＡ5y7xdfIRmN
917Please respect copyright.ＰＥＮＡＮＡEqvcWSJzkc
滿足3大條件後，病毒就有能力能夠入侵細胞。917Please respect copyright.ＰＥＮＡＮＡmBK7DzlbBU
當然，入侵細胞後還有很多因素決定武肺能否大量繁殖，但急凍雞翼連活生生的細胞也沒有，根本無可能可以大量繁殖。917Please respect copyright.ＰＥＮＡＮＡSvRD7Jmzgk
917Please respect copyright.ＰＥＮＡＮＡPQLxlVsu2K
何謂S protein和ACE2，可到我之前所寫的文章溫故知新。917Please respect copyright.ＰＥＮＡＮＡuE4C3IDeFn
https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/issue/9917Please respect copyright.ＰＥＮＡＮＡdOu9vsVsNf
917Please respect copyright.ＰＥＮＡＮＡSEqEW7RbOC
917Please respect copyright.ＰＥＮＡＮＡhevfxvGLfw
917Please respect copyright.ＰＥＮＡＮＡhj2EmCEg6a
（圖2）917Please respect copyright.ＰＥＮＡＮＡoZfNLRGu3L
第二點所謂的「啱嘴型」，所指的就是ACE2的形狀能否與武肺的S protein形狀吻合，就好像砌Puzzle一樣，兩者不吻合的話就無法連結一起，勉強亦無幸福。917Please respect copyright.ＰＥＮＡＮＡ2fwAV7MOE9
917Please respect copyright.ＰＥＮＡＮＡwrWNQbhdN6
如圖中所見，正因為老鼠ACE2唔啱嘴型，所以武肺無法引致老鼠患上肺炎等病徵，袁教授等人因此亦改用啱嘴型的倉鼠作為武肺的動物實驗模型。917Please respect copyright.ＰＥＮＡＮＡ4kXHe0PXPA
917Please respect copyright.ＰＥＮＡＮＡPK0oIT4kGu
（Ref 1)有科學家嘗試將武肺打落豬、雞和鴨身上，最終無法在牠們的任何器官身上找到武肺，而且亦沒有出現任何病徵，因此斷定牠們並不會受到武肺感染。917Please respect copyright.ＰＥＮＡＮＡi5XbzsB71x
917Please respect copyright.ＰＥＮＡＮＡWqGgoQZlw3
917Please respect copyright.ＰＥＮＡＮＡpHGfW1pjJT
（圖3）917Please respect copyright.ＰＥＮＡＮＡbVcSVutgx0
關於第三點，肺(Lung)及腎臟(Kidney)同樣擁有一定數量的ACE2及TMPRSS2（Ref2)，因此將會成為武肺的主要針對對象。917Please respect copyright.ＰＥＮＡＮＡ66KVUJiAte
917Please respect copyright.ＰＥＮＡＮＡWNPW1fPKLL
而心臟(Heart) 同樣擁有一定數量的ACE2，某程度亦解釋了為何武肺患者康復後會被發現心臟出現異樣。917Please respect copyright.ＰＥＮＡＮＡ4LoMmU0cGf
917Please respect copyright.ＰＥＮＡＮＡY1gj9m0OzC
917Please respect copyright.ＰＥＮＡＮＡENp0dqOqaV
而男性器官睪丸(Testis)，亦是ACE2數量較多的器官（圖中沒有列出），所以，嗯......917Please respect copyright.ＰＥＮＡＮＡAGYkMRQzfe
917Please respect copyright.ＰＥＮＡＮＡn0fAZ9vxFz
917Please respect copyright.ＰＥＮＡＮＡwQxwr93AyR
917Please respect copyright.ＰＥＮＡＮＡSSObDy3pUk
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。917Please respect copyright.ＰＥＮＡＮＡTnHCmVNKd8
917Please respect copyright.ＰＥＮＡＮＡX88Cvlw8b9
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc917Please respect copyright.ＰＥＮＡＮＡBWX8E4m2Dx
917Please respect copyright.ＰＥＮＡＮＡlzYZDxRLZ8
同時亦可以在Penana網站裡按「買一嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。917Please respect copyright.ＰＥＮＡＮＡoLrAE3Bqxg
917Please respect copyright.ＰＥＮＡＮＡRWv48Omvwp
Link:917Please respect copyright.ＰＥＮＡＮＡbyVujoKarr
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio917Please respect copyright.ＰＥＮＡＮＡmnLl6HGyrG
917Please respect copyright.ＰＥＮＡＮＡW8YDd7AQjP
917Please respect copyright.ＰＥＮＡＮＡKi4GC0CTcN
有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。917Please respect copyright.ＰＥＮＡＮＡAQl7OfVSb7
917Please respect copyright.ＰＥＮＡＮＡanPrmmNvuG
917Please respect copyright.ＰＥＮＡＮＡSSuSKSjpAw
917Please respect copyright.ＰＥＮＡＮＡvqL5pgBADG
917Please respect copyright.ＰＥＮＡＮＡnw67jsZZe0
917Please respect copyright.ＰＥＮＡＮＡLmRece3SMI
Ref1:https://science.sciencemag.org/content/368/6494/1016917Please respect copyright.ＰＥＮＡＮＡ8CEmtgLs0f
917Please respect copyright.ＰＥＮＡＮＡowoDoe0wdt
Ref2:https://www.sciencedirect.com/science/article/pii/S221323172030820X#fig1917Please respect copyright.ＰＥＮＡＮＡHpUSgWfOpo
Penana
search
Loginarrow_drop_down
Registerarrow_drop_down
