肌肉大概佔據身體重量的40%。481Please respect copyright.PENANA1B7DegWpG5481Please respect copyright.PENANAt5zTMchMD5
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。481Please respect copyright.PENANASLMSWbsx7S
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。481Please respect copyright.PENANAjcwVVsrDMx481Please respect copyright.PENANA1NmnlVaS6C
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。481Please respect copyright.PENANAtDuX0XZRkU
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。481Please respect copyright.PENANAal0KEkl22y
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。481Please respect copyright.PENANACDZPZGxNfT481Please respect copyright.PENANAlfo8s4jlvg
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。481Please respect copyright.PENANAr7bbLX7fjr
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。481Please respect copyright.PENANAbwtYBNl6UM
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。481Please respect copyright.PENANAdyAqXIm9kA
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。481Please respect copyright.PENANAyvsENsmN0m
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。481Please respect copyright.PENANAb0ytZXOmIG
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。481Please respect copyright.PENANA8bJp9rV3Nk
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio481Please respect copyright.PENANAo7YC879mTg
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。481Please respect copyright.PENANANkyoQguVeo
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059481Please respect copyright.PENANAOf35KuaLRU