化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?560Please respect copyright.PENANABPg1m2ORSG560Please respect copyright.PENANA0AfLPUILfX
560Please respect copyright.PENANA1Kk1HZsuLN
(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。560Please respect copyright.PENANAijQJUGUooH
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。560Please respect copyright.PENANA0q7ES2QqD7560Please respect copyright.PENANATrGNpGFKrk
560Please respect copyright.PENANAQea8VSgAsc
如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。560Please respect copyright.PENANA7V5jkpapZC
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。560Please respect copyright.PENANAYyyegrYYyS
560Please respect copyright.PENANAntXlDaT7CC
(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。560Please respect copyright.PENANA3gZAV9OC1P560Please respect copyright.PENANAEpPBKoP4wS
560Please respect copyright.PENANAd0uRM70N8r
560Please respect copyright.PENANA5uEHAAV5AM
(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。560Please respect copyright.PENANAyADAjpmtIG560Please respect copyright.PENANAbgRsQOxkUA
560Please respect copyright.PENANAqlXsyvazxL
但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。560Please respect copyright.PENANA5ygeWWwFNi
560Please respect copyright.PENANAcqoaz9t0Re
並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。560Please respect copyright.PENANABcaTH4n0ph
560Please respect copyright.PENANAhddicLxQKb
若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。560Please respect copyright.PENANAAoRzY26sSV
560Please respect copyright.PENANA8zCZ0iC2bg
560Please respect copyright.PENANAPkzBRuNbiu
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。560Please respect copyright.PENANAue1CzJajEo
560Please respect copyright.PENANA7fGBQdySFg
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc560Please respect copyright.PENANAHsSMEC1Zql
560Please respect copyright.PENANAeeaEyIGNCO
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。560Please respect copyright.PENANAZafv7dnNAZ
560Please respect copyright.PENANA8omc7Wl5f6
Link:560Please respect copyright.PENANAcZVJKeDW6z
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio560Please respect copyright.PENANA2VqMhYyocY
560Please respect copyright.PENANAjHUOX7Hex1
560Please respect copyright.PENANApHmbP2NkXx
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。560Please respect copyright.PENANAahKeQnufO6
560Please respect copyright.PENANASsGpsbDN7c
Ref1:https://www.nature.com/articles/s41467-020-14928-3560Please respect copyright.PENANAnWRMpwgO72